SIZE
0.1 mg
INTRODUCTION
Centromere proteins are a group of proteins which form and/or mediate the function of centromeres, the central structures of chromosomes to which spindle fibers/microtubuli attach and pull the chromosomes apart in cell division. The centromere protein A (CENPA) is one of them. CENPA contains a histone H3 related histone fold domain and can be incorporated into centromeric chromatin due to its histone-like properties. Anti-CENPA autoantibodies are an important marker for diagnosis of Scleroderma / CREST syndrome.
SIZE
0.1 mg
INTRODUCTION
Centromere proteins are a group of proteins which form and/or mediate the function of centromeres, the central structures of chromosomes to which spindle fibers/microtubuli attach and pull the chromosomes apart in cell division. The centromere protein A (CENPA) is one of them. CENPA contains a histone H3 related histone fold domain and can be incorporated into centromeric chromatin due to its histone-like properties. Anti-CENPA autoantibodies are an important marker for diagnosis of Scleroderma / CREST syndrome.
