SIZE
0.1 mg
INTRODUCTION
Goodpasture's disease (GP) is mediated by autoantibodies that bind the glomerular and alveolar basement membrane, causing rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. Type IV collagen, the major structural component of
glomerular basement membranes (GBM). The epitopes recognized by the Goodpasture autoantibodies are sequestered within the NC1 hexamer of the type IV collagen network.
Presence of anti-GBM antibodies confirms the diagnosis of Goodpasture Syndrome
DESCRIPTION
cDNA coding for a minicollagen version of the human collagen IV α3 chain fused to a
hexa-histidine purification tag. The term minicollagen designates the removal of most of
the epitope-less triplehelical collagenous region (situated between the N-terminal 7S
domain and the C-terminal noncollagenous NC1 domain). Expressed in insect cells with
total 280 AA. Mw: 30.6 KDa (calculated).
N-terminal 6xHis-tag and TEV cleavage site, 25 extra AA (highlighted).
Recombinant antigen for research use or manufacturing only.
SIZE
0.1 mg
INTRODUCTION
Goodpasture's disease (GP) is mediated by autoantibodies that bind the glomerular and alveolar basement membrane, causing rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. Type IV collagen, the major structural component of
glomerular basement membranes (GBM). The epitopes recognized by the Goodpasture autoantibodies are sequestered within the NC1 hexamer of the type IV collagen network.
Presence of anti-GBM antibodies confirms the diagnosis of Goodpasture Syndrome
DESCRIPTION
cDNA coding for a minicollagen version of the human collagen IV α3 chain fused to a
hexa-histidine purification tag. The term minicollagen designates the removal of most of
the epitope-less triplehelical collagenous region (situated between the N-terminal 7S
domain and the C-terminal noncollagenous NC1 domain). Expressed in insect cells with
total 280 AA. Mw: 30.6 KDa (calculated).
N-terminal 6xHis-tag and TEV cleavage site, 25 extra AA (highlighted).
Recombinant antigen for research use or manufacturing only.
