SIZE
0.1 mg
INTRODUCTION
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease with increasing annual incidence, recently estimated at 20 per million per year. It is associated with antibodies to proteinase 3 or myeloperoxidase and is generally considered as a disease affecting small blood vessels (‘small vessel vasculitis’). PR3 antibodies are most commonly associated with granulomatous polyangiitis (GPA), with peak incidence in 50 to 70 years old and affecting more men than women. Thus, PR3-ANCAs are well-known serological markers for diagnosis of GPA.
SIZE
0.1 mg
INTRODUCTION
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease with increasing annual incidence, recently estimated at 20 per million per year. It is associated with antibodies to proteinase 3 or myeloperoxidase and is generally considered as a disease affecting small blood vessels (‘small vessel vasculitis’). PR3 antibodies are most commonly associated with granulomatous polyangiitis (GPA), with peak incidence in 50 to 70 years old and affecting more men than women. Thus, PR3-ANCAs are well-known serological markers for diagnosis of GPA.
