SIZE
0.1 mg
INTRODUCTION
The fatty acid binding proteins (FABPs) are a family of carrier proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. The fatty acid binding protein 4 (FABP-4) and fatty acid binding protein 5(FABP5) are closely related and both are expressed in adipocytes. Mice with targeted disruption of FABP-4 accompany FABP-5 almost completely protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease. While mice over expressing FABP5 in adipose have reduced insulin sensitivity.
SIZE
0.1 mg
INTRODUCTION
The fatty acid binding proteins (FABPs) are a family of carrier proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. The fatty acid binding protein 4 (FABP-4) and fatty acid binding protein 5(FABP5) are closely related and both are expressed in adipocytes. Mice with targeted disruption of FABP-4 accompany FABP-5 almost completely protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease. While mice over expressing FABP5 in adipose have reduced insulin sensitivity.
