SIZE
0.1 mg
INTRODUCTION
Fibroblast growth factor 19 (FGF-19) is a member of a subfamily of FGFs that includes FGF-21 and FGF- 23, each member functions as an important regular of nutrient metabolism. The primary source of endocrine FGF-19 is the ileum, bile acids release into the intestine after a meal to induce expression of FGF-19. Circulating FGF-19 plays an important role in maintaining proper bile acid homeostasis. Several pharmacologic studies in hyperglycaemic, obese animal models have shown that FGF-19 can improve metabolic rate and lower serum glucose and hepatic triglyceride and cholesterol levels. Like insulin, FGF-19 functions as postprandial hormone to govern hepatic protein synthesis, glycogen synthesis and gluconeogenesis, but does not stimulate lipogenesis.
DESCRIPTION
Expressed in E.coli cells with total 194 AA. Mw: 21.6 KDa (calculated).
No tag, but with 2 extra AA at N-terminal (highlighted). Recombinant protein for research use or manufacturing only.
Recombinant antigen for research use or manufacturing only.
SIZE
0.1 mg
INTRODUCTION
Fibroblast growth factor 19 (FGF-19) is a member of a subfamily of FGFs that includes FGF-21 and FGF- 23, each member functions as an important regular of nutrient metabolism. The primary source of endocrine FGF-19 is the ileum, bile acids release into the intestine after a meal to induce expression of FGF-19. Circulating FGF-19 plays an important role in maintaining proper bile acid homeostasis. Several pharmacologic studies in hyperglycaemic, obese animal models have shown that FGF-19 can improve metabolic rate and lower serum glucose and hepatic triglyceride and cholesterol levels. Like insulin, FGF-19 functions as postprandial hormone to govern hepatic protein synthesis, glycogen synthesis and gluconeogenesis, but does not stimulate lipogenesis.
DESCRIPTION
Expressed in E.coli cells with total 194 AA. Mw: 21.6 KDa (calculated).
No tag, but with 2 extra AA at N-terminal (highlighted). Recombinant protein for research use or manufacturing only.
Recombinant antigen for research use or manufacturing only.
