SIZE
0.1 mg
INTRODUCTION
GDF-15 plays an important role in tumorigenesis and metastasis. It has been observed that in many types of cancers, such as colorectal, breast, and prostate, the expression of GDF-15 is dramatically increased.
Additionally, in cancer patients, serum levels of GDF-15 are elevated, which are of value in disease diagnosis and stratification. GDF-15 is strongly induced by the tumor suppressor gene p53 and other anti- tumorigenic agents, such as the non-steroidal anti-inflammatory drugs and peroxisome proliferators activated receptor γ. These findings suggest that GDF-15 may be a downstream target of those signaling pathways that regulate cell cycle arrest and apoptosis. Through the modulation of neuronal pathways important in the regulation of appetite and energy homeostasis, GDF-15 mediates cancer-induced anorexia and weight loss.
STRUCTURE AND ACTIVITY
Disulfide-linked homodimer.
10nM of recombinant hGDF15 is able to activate AKT and ERK phosphorylation in HEK293 cells co-transfected with the GDF15 receptor complex GFRAL and RET51.
SIZE
0.1 mg
INTRODUCTION
GDF-15 plays an important role in tumorigenesis and metastasis. It has been observed that in many types of cancers, such as colorectal, breast, and prostate, the expression of GDF-15 is dramatically increased.
Additionally, in cancer patients, serum levels of GDF-15 are elevated, which are of value in disease diagnosis and stratification. GDF-15 is strongly induced by the tumor suppressor gene p53 and other anti- tumorigenic agents, such as the non-steroidal anti-inflammatory drugs and peroxisome proliferators activated receptor γ. These findings suggest that GDF-15 may be a downstream target of those signaling pathways that regulate cell cycle arrest and apoptosis. Through the modulation of neuronal pathways important in the regulation of appetite and energy homeostasis, GDF-15 mediates cancer-induced anorexia and weight loss.
STRUCTURE AND ACTIVITY
Disulfide-linked homodimer.
10nM of recombinant hGDF15 is able to activate AKT and ERK phosphorylation in HEK293 cells co-transfected with the GDF15 receptor complex GFRAL and RET51.
