SIZE
96 wells/kit
INTENDED USE
SARS-CoV-2 S1RBD IgM ELISA Kit is a highly sensitive and specific immunoassay developed by ImmunoDiagnostics for quantitative detection of IgM class antibodies against the S1RBD of SARS-CoV-2 in human blood.
This product is intended for research use only.
BACKGROUND
SARS-CoV-2 is an enveloped virus with a positive-sense RNA genome and a nucleocapsid of helical symmetry. The SARS-CoV-2 entry into host cells is mediated by the transmembrane spike (S) glycoprotein, which is the main target of neutralizing antibodies upon infection and the focus of the therapeutic and vaccine design. S comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit). The distal S1 subunit comprises the receptor-binding domain (RBD) and contributes to stabilization of the prefusion state of the membrane-anchored S2 subunit that contains the fusion machinery. IgM is the first antibody to appear after infection, and the determination of IgM enables confirmation of SARS- CoV-2 infection in patients with symptoms.
SIZE
96 wells/kit
INTENDED USE
SARS-CoV-2 S1RBD IgM ELISA Kit is a highly sensitive and specific immunoassay developed by ImmunoDiagnostics for quantitative detection of IgM class antibodies against the S1RBD of SARS-CoV-2 in human blood.
This product is intended for research use only.
BACKGROUND
SARS-CoV-2 is an enveloped virus with a positive-sense RNA genome and a nucleocapsid of helical symmetry. The SARS-CoV-2 entry into host cells is mediated by the transmembrane spike (S) glycoprotein, which is the main target of neutralizing antibodies upon infection and the focus of the therapeutic and vaccine design. S comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit). The distal S1 subunit comprises the receptor-binding domain (RBD) and contributes to stabilization of the prefusion state of the membrane-anchored S2 subunit that contains the fusion machinery. IgM is the first antibody to appear after infection, and the determination of IgM enables confirmation of SARS- CoV-2 infection in patients with symptoms.
