SIZE
1000 tests/box
INTRODUCTION
Micro-albumin(mALB), also known as urine albumin, is an important blood protein predominantly made by liver tissue that balances the blood osmotic pressure and transports hormones, vitamins, and substances like calcium throughout human body. Under normal circumstances, micro- albumin with 66kDa molecular weight is too large to cross the glomerular basal membrane. During kidney diseases, the pathological damage to the glomerular membrane leads to changes in permeability, and eventually causes micro-albumin excess excretion in urine. Therefore, micro-albumin is a sensitive and decisive biomarker for kidney injury. Micro-albumin test can timely detect kidney disease at early stage and help doctors make a right diagnosis to prevent deterioration. A higher level of micro-albumin in urine indicated the more severe kidney damage.
The reference of micro- albumin in health human is less than 20mg/L, and Reversible renal injury is among 20mg/L to 200mg/L, and Irreversible renal injury (renal failure or uremia) is above 200mg/L.
PRINCIPLE OF THE ASSAY
This assay is a turbidimetric immunoassay for the quantitative measurement of micro-albumin in human urine. A standard or sample is added into a cuvette and mixed with the reaction buffer R1. After a short incubation, the test reagent R2, which is a suspension of microparticles coated with an antibody highly specific to micro-albumin, is added into the cuvette and mixed. The presence of micro-albumin in the standard or sample causes the immune-particles to aggregate. The extent to which the microparticles aggregate is quantified by the amount of light scattering measured as absorbance by a chemistry analyzer. The concentration of Micro-albumin in unknown samples can be interpolated from a reference curve using the standards provided.
SIZE
1000 tests/box
INTRODUCTION
Micro-albumin(mALB), also known as urine albumin, is an important blood protein predominantly made by liver tissue that balances the blood osmotic pressure and transports hormones, vitamins, and substances like calcium throughout human body. Under normal circumstances, micro- albumin with 66kDa molecular weight is too large to cross the glomerular basal membrane. During kidney diseases, the pathological damage to the glomerular membrane leads to changes in permeability, and eventually causes micro-albumin excess excretion in urine. Therefore, micro-albumin is a sensitive and decisive biomarker for kidney injury. Micro-albumin test can timely detect kidney disease at early stage and help doctors make a right diagnosis to prevent deterioration. A higher level of micro-albumin in urine indicated the more severe kidney damage.
The reference of micro- albumin in health human is less than 20mg/L, and Reversible renal injury is among 20mg/L to 200mg/L, and Irreversible renal injury (renal failure or uremia) is above 200mg/L.
PRINCIPLE OF THE ASSAY
This assay is a turbidimetric immunoassay for the quantitative measurement of micro-albumin in human urine. A standard or sample is added into a cuvette and mixed with the reaction buffer R1. After a short incubation, the test reagent R2, which is a suspension of microparticles coated with an antibody highly specific to micro-albumin, is added into the cuvette and mixed. The presence of micro-albumin in the standard or sample causes the immune-particles to aggregate. The extent to which the microparticles aggregate is quantified by the amount of light scattering measured as absorbance by a chemistry analyzer. The concentration of Micro-albumin in unknown samples can be interpolated from a reference curve using the standards provided.
